Depression is a leading cause of disability and suffering worldwide. 300 million people suffer from depression globally, costing the world economy USD 1 trillion in lost productivity.

Depression costs the Australian economy AUD 6 billion in direct and indirect costs..

1 in 3 patients recovering from their first depression episode is likely to relapse, turning depression into a chronic disease.

Prolonged sympathetic nervous arousal or fight or flight activity in the body is a leading risk factor for depression relapse.